ncRNA name | HO-1 siRNA |
ncRNA Category | siRNA |
Disease name | choroidal neovascularization (CNV) |
Species | Homo sapiens |
Tissues/Cell_line | RPE cell line ARPE-19 |
Methods | siRNA transfection, semi-qRT–PCR, Western blot, cell proliferation assay, migration assay, tube formation assay |
Expression pattern | associated |
Functional description | Knockdown of HO-1 expression and inhibition of HO-1 activity resulted in potent reduction of the expression of vascular endothelial growth factor (VEGF) under hypoxia. Furthermore, knockdown of HO-1 suppressed the proliferation, migration and tube formation of cocultured endothelial cells. |
PubMed ID | 23583371 |
Year | 2013 |
Title | Silencing heme oxygenase-1 gene expression in retinal pigment epithelial cells inhibits proliferation, migration and tube formation of cocultured endothelial cells. |
Drug-related ncRNA | NO |
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